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Clinician-Approved Probiotic Supplement for Constipation Support

IB-ONE™ Formulated with Bacillus coagulans Unique IS-2™ (MTCC 5260), a single-strain probiotic clinically studied at 2 billion CFUs per day.

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Bowel movements Improved From 1 to 6 Per week

In this clinical study the number of spontaneous bowel movements (SBMs) per week increased from 0.9 at baseline to 5.98 at end-of-treatment (week 4).†^

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At Week 3 and Week 4, there was a signifivant improvement in the B. coagulans Unique IS-2 group compared to placebo (p < 0.001).

From 0% to 98% of subjects having normal stool consistency<span class="symbol">†^<span>

  • Treatment

    Bacillus coagulans Unique IS2 (n = 50)

    Parameters

    Baseline

    Day 15 ± 2

    End of study

    Constipated Stool

    50 (100%)

    38 (76%)

    1 (2%)

    Normal Stool

    0

    12 (24%)

    49 (98%)

  • Treatment

    Placebo (n = 50)

    Parameters

    Baseline

    Day 15 ± 2

    End of study

    Constipated Stool

    50 (100%)

    42 (84%)

    13 (26%)

    Normal Stool

    0

    8 (16%)

    37 (74%)

    n = number

MIOME® Clinician Partners

Hear from our growing network of expert clinicians who recommend MIOME to their patients.

  • Studied to relieve constipation

    "I often didn’t recommend probiotics for constipation as a gut health dietitian due to the lack of clinical research. But one that I’m now excited to recommend specifically is Bacillus coagulans Unique IS-2™ (MTCC 5260) – a single-strain probiotic clinically studied to relieve constipation at 2 billion CFUs per day."

    Leigh Merotto

    Leigh Merotto

    RD, MHSc

    Registered Dietitian

    leighmerotto_rd #partner leighmerotto.com

  • A research-backed strain

    "I’m tired of seeing probiotics that lack real clinical evidence. My clients have tried so many different probiotics, yet they still come to me with the same gut issues. That’s exactly why I’m excited about IB-ONE by MIOME. It features a research-backed strain that actually works: Bacillus coagulans Unique IS-2 (MTCC 5260) - shown to support constipation, bloating, and abdominal discomfort. As a gut health dietitian, I rarely say this… but I’m impressed."

    Beth Nanson

    Beth Nanson

    RD

    Registered Dietitian

    gut.ibs.dietitian #partner bethnansonrd.com

  • More bowel movements

    "At the start of the study [Unique IS-2 strain in IB-ONE], not a single participant had normal consistency of bowel movement, which was assessed by the Bristol stool chart. But after 4 weeks of taking the probiotic, 98% had normal consistency. So more frequency, more bowel movements overall, with better consistency. That's real, measurable support, which as a practitioner is exactly what I wanna see to even make a recommendation."

    Erin Judge

    Erin Judge

    RDN

    Registered Dietitian

    erinjudge.rd #partner gutivate.com

IB-ONE™ 20MG

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30 CAPSULES

IB-ONE™ 20MG

The Probiotic Clinicians Recommend for Constipation

If you've cycled through laxatives, fiber supplements & generic probiotics with little success, IB-ONE™ was formulated for you. One clinically-studied strain. The right dose. Recommended by gastroenterologists, doctors & dietitians to their own patients.

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Allergen-conscious

IB-ONE™ is formulated for sensitive GI systems & free from the most common triggers.

  • LOW FODMAP
    LOW FODMAP
  • NON GMO
    NON GMO
  • GLUTEN FREE
    GLUTEN FREE
  • DAIRY FREE
    DAIRY FREE
  • SOY FREE
    SOY FREE

There’s only one IB-ONE™

There’s only one IB-ONE™

*Per Best Sellers in "Constipation Probiotics" category on Amazon.com

There’s only one IB-ONE™ There’s only one IB-ONE™
Top 5 Selling Probiotics in USA*

  • Probiotic strain featured in 20+ human clinical studies

    <p>Probiotic strain featured in 20+ human clinical studies</p>
    <p>Probiotic strain featured in 20+ human clinical studies</p>

  • Dosed based on clinical studies

    <p>Dosed based on clinical studies</p>
    <p>Dosed based on clinical studies</p>

  • Third-party published testing for allergens, contaminants & heavy metals

    <p>Third-party published testing for allergens, contaminants & heavy metals</p>
    <p>Third-party published testing for allergens, contaminants & heavy metals</p>

  • Blister foil packaging for stability, hygiene & shelf-life

    <p>Blister foil packaging for stability, hygiene & shelf-life</p>
    <p>Blister foil packaging for stability, hygiene & shelf-life</p>

  • Probiotic strain that survives stomach acid

    <p>Probiotic strain that survives stomach acid</p>
    <p>Probiotic strain that survives stomach acid</p>

  • 8 week satisfaction program 

    <p>8 week satisfaction program </p>
    <p>8 week satisfaction program </p>

FEATURED IN

MIOME’s IB-ONE has been selected in AEProbio’s 2025 Clinical Guide to Probiotics

visit usprobioticguide.com

From Their Guide

  • The Clinical Guide to Probiotics Available in the United States

    This guide is a practice tool to assist with clinical decision-making for appropriate probiotic therapy for your patients.


    It is designed to translate scientific evidence available for probiotic products to practical, clinically relevant information. It is intended to be used as a clinical decision-making tool, enabling clinicians to easily select the appropriate product, dose and formulation for a specific indication.

  • Why are only a limited number of products included?

    All of the inclusion criteria listed below must be satisfied for a product to be listed in this clinical guide:


    1) Commercially available in the United States as a dietary supplement or probiotic-containing food


    2) Generally Recognized as Safe status (FDA) and/or Natural Product Number (Health Canada) for probiotic strain(s) used in the products


    3) Favorable published clinical evidence for the particular strain(s) present in each product/food


    4) For products containing multiple strains, the evidence must be for the specified combination and NOT extrapolated from the evidence for the separate probiotic strains

  • How is the Guide Reviewed?

    A systematic literature review using pre-defined inclusion criteria was undertaken to identify studies of defined clinical outcomes for specific probiotic strain(s). Commercially available products containing said strain(s) were identified, and the levels of evidence were used to rate the strength of the expected benefit. This information was compiled into a chart format. Data was assessed by a group of independent expert reviewers.



    In the case of probiotics, the clinical evidence must be linked to specific formulations as defined by genus, species, alphanumeric designation or strain, number of live bacteria present, the blend of probiotic strains present and finally, non-active ingredients present.

One Strain, Many Benefits One Strain, Many Benefits
One Strain, Many Benefits

One Strain, Many Benefits

Results from clinical studies on Unique

IS-2™ TCC 5260 show it supports:

  • Support Normal Bowel Movements<span class="symbol">†</span>

    "In the present investigation, we have shown that B. coagulans Unique IS2 (2 billion CFU) significantly improved the number of bowel movements per week..."


    - Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

  • Promote Stool Consistency<span class="symbol">†</span>

    "Ninety eight percent [98%] of subjects in the probiotic group achieved normal stool consistency."

    - Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

  • Maintain Abdominal Comfort<span class="symbol">†</span>

    "The significant reduction of sensation of incomplete evacuation, defecation-, and abdominal-[discomfort] correlated with the strains ability to produce short-chain fatty acids."


    - Venkataraman et al, J. Probiotics. Ant. Pro. 2023; PubMed ID: 34599466

  • Targeted Delivery<span class="symbol">†</span>

    "Being a spore former, B. coagulans Unique IS2 is resistant to acidic conditions of the stomach and bile acids. It reaches the intestine without any loss of viability where it produces lactic acid."

    - Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

Our 3rd Party Testing

What's on the label is what's in the capsule. IB-ONE™ is verified for potency at 2 billion CFUs per serve and tested for allergens, contaminants & heavy metals.

Our 3rd Party Testing

  • Potency

    • CFUs
      PASS

  • Allergens

    • Gluten
      PASS
    • Dairy (Milk & Casein)
      PASS
    • Soy
      PASS

  • Microbiological Contaminants

    • Aerobic Plate Count
      PASS
    • Yeast & Mold
      PASS
    • E. coli - Coliform
      PASS
    • Enterobacteriaceae
      PASS
    • S. aureus
      PASS

  • Heavy Metals

    • Antimony
      PASS
    • Arsenic
      PASS
    • Beryllium
      PASS
    • Cadmium
      PASS
    • Lead
      PASS
    • Mercury
      PASS
    • Nickel
      PASS
    • Selenium
      PASS
Our 3rd Party Testing

foil blister packaging:

Why it matters for probiotics

  • Protection From Moisture & Oxygen

    Probiotics are highly sensitive to humidity and air exposure. Foil blister packs seal each capsule individually, providing a strong barrier that keeps out moisture and oxygen - both major threats to probiotic stability.

  • Stability & Shelf Life of Probiotics

    With bottles, every time you open the lid, the entire batch of probiotics is exposed. Blister packs isolate each dose, helping maintain potency over time.

  • Dosing Accuracy & Hygiene

    Blister packs ensure you only touch what you take. This avoids contamination of other capsules and keeps the rest of the product stable and protected.

  • Convenience Without Compromise

    Blister packs are compact, travel-friendly and allow for easy tracking of daily doses. No need to carry an entire bottle or worry about the rest of your probiotics losing efficacy on the go.

24/7 Protection

Your capsules are housed in blister foil packaging, protecting them from light, moisture & oxygen; ensuring maximum potency from production to consumption.

Shelf-Stable Convenience

Store your probiotics at room temperature with confidence, as our products remain effective without the need for refrigeration.

Smart Capsules

Our capsules are designed to dissolve in the GI tract, delivering probiotics where they are needed most.

The Details Matter

The Details Matter

IB-ONE™

No Unnecessary Fillers

Enjoy small, easy-to-swallow capsules that contain no unnecessary fillers, providing you with simply the ingredients you need.

No Coatings

We avoid using color coatings and enteric coatings, as they are not necessary for optimal delivery of the active ingredients in our formulations.

No Gluten, Dairy or Soy

Our products are free from gluten, dairy, and soy, ensuring they are suitable for those with dietary restrictions.

  • 24/7 Protection

    Your capsules are housed in blister foil packaging, protecting them from light, moisture & oxygen; ensuring maximum potency from production to consumption.

  • Shelf-Stable Convenience

    Store your probiotics at room temperature with confidence, as our products remain effective without the need for refrigeration.

  • Smart Capsules

    Our capsules are designed to dissolve in the GI tract, delivering probiotics where they are needed most.

  • No Unnecessary Fillers

    Enjoy small, easy-to-swallow capsules that contain no unnecessary fillers, providing you with simply the ingredients you need.

  • No Coatings

    We avoid using color coatings and enteric coatings, as they are not necessary for optimal delivery of the active ingredients in our formulations.

  • No Gluten, Dairy or Soy

    Our products are free from gluten, dairy, and soy, ensuring they are suitable for those with dietary restrictions.

MIOME® Clinician Partners

Hear from our growing network of expert clinicians who recommend MIOME to their patients.

  • Not all probiotics are the same

    "As a GI doctor, I always say strain matters. Most probiotics don't do much for constipation, but this one actually worked for me. It has Bacillus coagulans Unique IS-2, which is a clinically studied strain that's been hard to find in the US until now."

    Dr. Rucha Shah MD

    Dr. Rucha Shah MD

    Gastroenterologist

    Board Certified Gastroenterologist

    gastrohealthmd #partner honorhealth.com

  • 1 to 6 bowel movements per week

    "This is a strain shown to actually help specifically with constipation. Like in this study where people with constipation went from less than 1 to nearly 6 bowel movements per week after taking this strain for four weeks."

    Kirsten Jackson

    Kirsten Jackson

    RD

    Gastroenterology Registered Dietitian

    the.ibsdietitian #partner theibsdietitian.com

  • Support stool consistency

    "98% of people went from hard pebble poos to healthier sausage shaped ones. And most participants in this clinical study [of Unique IS-2 strain] said they finally felt like they could fully empty their bowels again."

    Kate Spina

    Kate Spina

    GI Nutritionist

    Qualified Practicing Nutritionist

    ibs.sibo.nutritionist #partner katespinanutrition.com
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8 Week Satisfaction Program

Try IB-ONE™ Risk-Free

In clinical studies using this probiotic strain, many participants experienced benefits within 2 weeks, with most improvements by week 4 onwards. To give you enough time to see how IB-ONE™ works for you, we offer a no-questions-asked 8 Week Satisfaction Program. If you're not completely satisfied, simply return it for a full refund.

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Frequently Asked Questions

You can take IB-ONE™ any time of day. For optimal results, try to take it at the same time each day.

Some probiotic companies advise taking their products with a meal to ensure the best survival rate through the body's gastric acidity. Others suggest taking them on an empty stomach to limit exposure to digestive enzymes and bile.

However, IB-ONE™ is a spore-forming probiotic, naturally resistant to stomach acid and intestinal factors. This flexibility means you can take it at any time of day that fits your routine, without worrying about its effectiveness.

You can take IB-ONE™ with or without food.

While other probiotic companies advise taking their products with a meal to ensure the best survival rate through gastric acidity, while others suggest an empty stomach to avoid digestive enzymes and bile.

With IB-ONE™, timing isn’t an issue. As a spore-forming probiotic, it is naturally resistant to stomach acid and intestinal factors. This means you can take it with or without food, at any time of day that fits your routine, without compromising its effectiveness. Whether with breakfast, lunch, dinner, or on an empty stomach, IB-ONE™ easily fits into your daily routine.

Yes, you can.

IB-ONE™ is a spore-forming probiotic, naturally resistant to stomach acid. Unlike other probiotics that need special coatings (i.e. enteric / delayed release capsules) to survive gastric acid and must remain in the capsule when taken, IB-ONE™ can be opened and mixed with your food or drink without losing effectiveness. While the capsules are easy to swallow, you have the flexibility to take it in whatever way is most convenient for you.

Yes, IB-ONE™ is suitable for most diets and dietary restrictions.

IB-ONE™ is free from common allergens and contains no animal-derived ingredients, making it vegetarian-friendly. It is also independently tested by third parties for gluten, dairy (including milk and casein) and soy, to ensure it meets the highest standards.

IB-ONE™ is suitable for a variety of diets, including Low FODMAP, Vegan, Vegetarian, Ketogenic, Gluten-Free, Paleo, Mediterranean, and more. This versatility makes IB-ONE™ an inclusive option for supporting your gut health, no matter your dietary needs.

No, IB-ONE™ does not need to be refrigerated.

Our spore-forming probiotic is designed to be shelf-stable at room temperature, maintaining its potency without the need for refrigeration.

This makes it convenient for you to take your probiotics with you wherever you go.

In clinical studies (Madempudi et al. 2020) using Unique IS-2™️ MTCC 5260, participants began to notice support from day 15 (week 3) onwards.

This means you might start to experience the effects after 2 weeks of daily use, with the most significant benefits typically becoming evident after 4 weeks of consistent use.

To give you enough time to see how MIOME works for you, we offer a no-questions-asked 8 Week Satisfaction Program. If you're not completely satisfied, simply return your product for a full refund.

International shipping is now LIVE!

We now ship to over 220 countries. Duties and taxes are calculated upfront at checkout, which means no surprise fees on delivery, and no customs hassle on your end. Just add to cart, check out, and we'll handle the rest.