IB-ONE™ 20MG

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1 5
30 CAPSULES

IB-ONE™ 20MG

IB-ONE™ 20MG

Supports normal bowel movements & digestive health †

  • Made exclusively with Unique IS-2™️ MTCC 5260 probiotic strain
  • Clinically studied to support gut health in as little as 2 weeks - View studies
  • Dosed based on clinical studies - take just 1 capsule (2b CFUs / 20mg) per day 
  • Designed for sensitive guts - low FODMAP, gluten free & non-GMO
  • 3rd party tested for allergens, heavy metals & contaminants - View results
8 Week Satisfaction Program

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Size
Clinical Studies
Supplement facts
  • Low FODMAP
  • GMO free
  • Gluten free
  • Dairy free
  • Soy free

HOW TO TAKE

Take 1 capsule per day.

IB-ONE™ contains a strain that can survive stomach acid and can be taken with or without food, at any time of day.

Shelf stable: No refrigeration required.

PACKAGING

IB-ONE™ comes in protective foil blister packaging to ensure the probiotics remain potent. Each box contains three blisters, each with 10 capsules, for a total of 30 capsules. The blisters are housed in a recyclable cardboard box, making it easy to store and environmentally friendly.

INGREDIENTS

Active Ingredient: Bacillus coagulans Unique IS-2™ (MTCC 5260, ATCC PTA-11748): 2 Billion CFU (20 mg)**

Other Ingredients: Microcrystalline Cellulose, Vegetarian Capsule (Cellulose, Water), Vegetable Stearate, Silicon Dioxide

**Daily Value (DV) not established.

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  • Clinical Studies

    Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study

    Functional constipation has a high prevalence in both adults and children affecting quality of life. Evidence suggests that probiotics can reduce the symptoms of constipation. As the effects of probiotics are strain specific, the efficacy of Bacillus coagulans Unique IS2 in the treatment of functional constipation in adults was evaluated. Subjects (n = 100) diagnosed with functional constipation were supplemented with either B. coagulans Unique IS2 (2 billion CFU) or placebo capsules once daily for 4 weeks.

    Subjects were evaluated for treatment success (defined as three or more spontaneous stools per week), stool consistency, difficulty of defecation, defecation and abdominal pain. By the end of the fourth week, there was a statistically significant (p < 0.001) increase in number of bowel movements in the probiotic treated group as compared to placebo. Ninety eight percent of subjects in the probiotic group achieved normal stool consistency as compared to placebo (74%). Moreover, there was relief from symptoms of incomplete evacuation, painful defecation and abdominal pain associated with constipation in probiotic treated group as compared to placebo.

    In conclusion, B. coagulans Unique IS2 significantly decreased the symptoms of constipation indicating effectiveness of the strain in the treatment of constipation.Trial registration: CTRI/2017/11/010539.

    View study (PubMed)

    Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020 Jun;12(2):335-342. doi: 10.1007/s12602-019-09542-9. PMID: 30911991.

  • Clinical Studies

    Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study 2

    Functional constipation has a high prevalence in both adults and children affecting quality of life. Evidence suggests that probiotics can reduce the symptoms of constipation. As the effects of probiotics are strain specific, the efficacy of Bacillus coagulans Unique IS2 in the treatment of functional constipation in adults was evaluated. Subjects (n = 100) diagnosed with functional constipation were supplemented with either B. coagulans Unique IS2 (2 billion CFU) or placebo capsules once daily for 4 weeks. 2

    View study (PubMed)

    Madempudi RS, Neelamraju J, Ahire JJ, Gupta SK, Shukla VK. Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study. Probiotics Antimicrob Proteins. 2020 Jun;12(2):335-342. doi: 10.1007/s12602-019-09542-9. PMID: 30911991. 2

  • Supplement Facts

    Other Ingredients: Microcrystalline Cellulose, Vegetarian Capsule (cellulose, water), Vegetable Stearate, Silicon Dioxide.

One Strain, Many Benefits

Results from clinical studies on Unique IS-2™️ MTCC 5260 show it supports:

Support Normal Bowel Movements†

"In the present investigation, we have shown that B. coagulans Unique IS2 (2 billion CFU) significantly improved the number of bowel movements per week..."

- Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

Maintain Abdominal Comfort†

"The significant reduction of sensation of incomplete evacuation, defecation-, and abdominal-[discomfort] correlated with the strains ability to produce short-chain fatty acids."

- Venkataraman et al, J. Probiotics. Ant. Pro. 2023; PubMed ID: 34599466

Promote Stool Consistency†

"Ninety eight percent [98%] of subjects in the probiotic group achieved normal stool consistency."

- Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

Targeted Delivery†

"Being a spore former, B. coagulans Unique IS2 is resistant to acidic conditions of the stomach and bile acids. It reaches the intestine without any loss of viability where it produces lactic acid."

- Madempudi et al, J. Probiotics. Ant. Pro. 2020; PubMed ID: 30911991

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Clinically Studied Probiotics

Formulated exclusively with Unique IS-2™ and dosed according to clinical study protocols.

Unique IS-2™️
Unique IS-2™️ MTCC 5260, ATCC PTA-11748, is a Bacillus coagulans probiotic strain that has been extensively studied in over 20 human clinical trials, including 8 specifically focused on digestive health. These clinical studies have been conducted between 2011 and present, with more trials planned. This ongoing research highlights the strain's remarkable efficacy and safety profile.
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The Details Matter

No unnecessary fillers
Formulated without gluten, dairy & soy
Vegetable capsules free of animal products
Shelf stable convenience - no refrigeration required
Blister packaging to protect from light, moisture & oxygen
Capsules that release active ingredients in the GI tract - where they are needed
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8 Week Satisfaction Program

Experience IB-ONE™ Risk-Free

In clinical studies using this probiotic strain, participants experienced benefits within 2 weeks, with most improvements by week 4 onwards. To give you enough time to see how IB-ONE™ works for you, we offer a no-questions-asked 8 Week Satisfaction Program. If you're not completely satisfied, simply return it for a full refund.

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Frequently Asked Questions

You can take IB-ONE™ any time of day. For optimal results, try to take it at the same time each day.

Some probiotic companies advise taking their products with a meal to ensure the best survival rate through the body's gastric acidity. Others suggest taking them on an empty stomach to limit exposure to digestive enzymes and bile.

However, IB-ONE™ is a spore-forming probiotic, naturally resistant to stomach acid and intestinal factors. This flexibility means you can take it at any time of day that fits your routine, without worrying about its effectiveness.

You can take IB-ONE™ with or without food.

While other probiotic companies advise taking their products with a meal to ensure the best survival rate through gastric acidity, while others suggest an empty stomach to avoid digestive enzymes and bile.

With IB-ONE™, timing isn’t an issue. As a spore-forming probiotic, it is naturally resistant to stomach acid and intestinal factors. This means you can take it with or without food, at any time of day that fits your routine, without compromising its effectiveness. Whether with breakfast, lunch, dinner, or on an empty stomach, IB-ONE™ easily fits into your daily routine.

Yes, you can.

IB-ONE™ is a spore-forming probiotic, naturally resistant to stomach acid. Unlike other probiotics that need special coatings (i.e. enteric / delayed release capsules) to survive gastric acid and must remain in the capsule when taken, IB-ONE™ can be opened and mixed with your food or drink without losing effectiveness. While the capsules are easy to swallow, you have the flexibility to take it in whatever way is most convenient for you.

Yes, IB-ONE™ is suitable for most diets and dietary restrictions.

IB-ONE™ is free from common allergens and contains no animal-derived ingredients, making it vegetarian-friendly. It is also independently tested by third parties for gluten, dairy (including milk and casein) and soy, to ensure it meets the highest standards.

IB-ONE™ is suitable for a variety of diets, including Low FODMAP, Vegan, Vegetarian, Ketogenic, Gluten-Free, Paleo, Mediterranean, and more. This versatility makes IB-ONE™ an inclusive option for supporting your gut health, no matter your dietary needs.

No, IB-ONE™ does not need to be refrigerated.

Our spore-forming probiotic is designed to be shelf-stable at room temperature, maintaining its potency without the need for refrigeration.

This makes it convenient for you to take your probiotics with you wherever you go.

In clinical studies (Madempudi et al. 2020) using Unique IS-2™️ MTCC 5260, participants began to notice symptom support from day 15 (week 3) onwards.

This means you might start to experience the effects after 2 weeks of daily use, with the most significant benefits typically becoming evident after 4 weeks of consistent use.

To give you enough time to see how MIOME works for you, we offer a no-questions-asked 8 Week Satisfaction Program. If you're not completely satisfied, simply return your product for a full refund.

We are planning to expand our international shipping options later this year. In the meantime, you can access our products using a mail forwarding service like MyUS.com. MyUS offers extremely competitive international shipping rates and is very easy to use.

Simply sign up for an account, and they will provide you with a U.S. address to use for your Miome orders. Once your order arrives at their facility, MyUS will forward it to your international address.

This way, you can enjoy our products no matter where you are.